PHF5A

Across TCGA cell cohorts, PHF5A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,475 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PHF5A-associated GO terms across cancer lineages are DNA replication, DNA replication initiation, and DNA-templated DNA replication. Each is linked with PHF5A in more than 15 cancer types. Because this analysis shows association rather than direction, both PHF5A-to-partner and partner-to-PHF5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by PHF5A-low versus PHF5A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF5A→partner) and Y-score (partner→PHF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.082	+0.786	<.001	<.001	3	16
BLOOD_Myeloma	DNA replication initiation →	+0.172	+0.741	.001	.002	3	16
BONE	DNA-templated DNA replication →	+0.163	+0.628	.001	.001	3	15
BONE	Mitotic sister chromatid cohesion →	+0.170	+0.891	<.001	<.001	3	15
KIDNEY	Double-strand break repair via break-induced replication →	+0.188	+0.657	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.184	+1.083	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,475 associations by consensus.

DNA replication by PHF5A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →