PHF23

Across TCGA pan-cancer cohorts, PHF23 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHF23 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHF23 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PHF23 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PHF23 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.840	.037	4	view →
HNSC	OS	Median	All	1.000	0.959	.023	4	view →
LSCC	OS	Tertile	All	0.884	0.691	.047	3	view →
LUAD	OS	Median	II,III,IV	0.467	0.907	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHF23–CCRCC (OS)

Open the CCRCC breakdown →