PHF23

Across TCGA pan-cancer cohorts, PHF23 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PHF23’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PHF23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHF23 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where PHF23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHF23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.728	<.001	12	view →
KICH	Female	III,IV	−2.026	<.001	8	view →
LIHC	Male	II,III,IV	+0.829	<.001	8	view →
LUAD	All	III,IV	+0.545	<.001	8	view →
UCEC	All	III,IV	+0.608	.018	6	view →
BRCA	All	All	+0.223	.002	6	view →
CHOL	Male	All	+1.981	<.001	5	view →
LUSC	Male	All	+0.430	<.001	5	view →
THCA	Female	All	+0.328	<.001	4	view →
STAD	All	II,III,IV	+0.421	.012	2	view →
BLCA	All	All	+0.352	.033	2	view →
PAAD	Female	All	+0.264	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PHF23–HNSC

Open the HNSC breakdown →