PHF23

Across TCGA cell cohorts, PHF23 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF23-associated genes across cancer lineages are FMO1, RFX4, and TBR1. Each is linked with PHF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF23-to-partner and partner-to-PHF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by PHF23-low versus PHF23-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF23→partner) and Y-score (partner→PHF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.115	+4.144	<.001	<.001	3	1
LARGE_INTESTINE	RFX4 →	+0.036	+3.029	<.001	.003	3	1
LARGE_INTESTINE	TBR1 →	+0.041	+3.555	<.001	.003	3	1
LARGE_INTESTINE	TMSB4Y →	+1.005	+3.374	.003	.005	3	1
LARGE_INTESTINE	FANCD2OS →	+0.123	+3.584	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FMO1 by PHF23 expression — LARGE_INTESTINE

Explore this box plot interactively →