PHF21A

Across TCGA pan-cancer cohorts, PHF21A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHF21A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PHF21A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHF21A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where PHF21A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.657	0.863	.009	13	view →
CCRCC	OS	Median	II,III,IV	0.133	0.985	.027	7	view →
LSCC	OS	Median	All	1.000	0.937	.012	4	view →
PDAC	OS	Tertile	II,III,IV	0.275	0.549	.029	4	view →
HNSC	OS	Quartile	III,IV	0.728	0.913	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHF21A–LUAD (OS)

Open the LUAD breakdown →