PHF21A

Across TCGA pan-cancer cohorts, PHF21A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PHF21A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PHF21A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHF21A is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where PHF21A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHF21A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.747	<.001	12	view →
LIHC	Female	II,III,IV	+1.256	<.001	9	view →
HNSC	All	All	+0.366	.001	6	view →
UCEC	All	All	−0.699	<.001	4	view →
BRCA	Female	All	−0.159	.007	4	view →
CHOL	Female	All	+2.936	<.001	3	view →
BLCA	All	IV	−0.878	.019	2	view →
KICH	All	All	−0.402	.008	2	view →
LUSC	All	All	+0.237	.015	1	view →
THCA	All	All	−0.236	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PHF21A–KIRC

Open the KIRC breakdown →