PHF21A

Across TCGA patient cohorts, PHF21A mutation is significantly associated with the RNA expression of many other genes, with 4,306 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF21A-associated genes across cancer lineages are KDM1A, LINC02557, and ITGB3BP. Each is linked with PHF21A in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF21A-to-partner and partner-to-PHF21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM1A grouped by PHF21A-low versus PHF21A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21A→partner) and Y-score (partner→PHF21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KDM1A →	+0.431	+2.606	<.001	<.001	3	3
LUSC	LINC02557 →	+0.113	+3.785	.001	.001	3	3
UCEC	ITGB3BP →	+0.410	+2.425	<.001	.001	3	3
UCEC	RPF2 →	+0.377	+1.562	.003	.002	3	3
UCEC	C1orf174 →	+0.439	+2.283	<.001	<.001	3	3
UCEC	PGAM5 →	+0.642	+2.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

KDM1A by PHF21A expression — UCEC

Explore this box plot interactively →