PHF21A

Across TCGA patient cohorts, PHF21A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF21A-associated genes across cancer lineages are MEK1, Cyclin-B1, and Cyclin-E2. Each is linked with PHF21A in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF21A-to-partner and partner-to-PHF21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PHF21A-low versus PHF21A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21A→partner) and Y-score (partner→PHF21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.372	+2.000	.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.603	+2.662	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.119	+1.425	.029	.027	3	3
UCEC	EGFR_pY1068 →	-0.236	-2.321	.003	<.001	3	2
UCEC	Gab2 →	+0.423	+3.807	<.001	<.001	3	2
UCEC	Notch1 →	+0.197	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by PHF21A expression — UCEC

Explore this box plot interactively →