PHF21A

Across TCGA cell cohorts, PHF21A mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF21A-associated genes across cancer lineages are OR2L8, MRGPRX2, and USP29. Each is linked with PHF21A in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF21A-to-partner and partner-to-PHF21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by PHF21A-low versus PHF21A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF21A→partner) and Y-score (partner→PHF21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.012	+4.681	<.001	.003	3	2
SKIN	MRGPRX2 →	+0.006	+4.977	<.001	.007	3	2
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR7G2 →	+0.032	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR5M1 →	+0.020	+6.569	<.001	<.001	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.019	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR2L8 by PHF21A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →