PHF20L1

Across TCGA patient cohorts, PHF20L1 mutation is significantly associated with the RNA expression of many other genes, with 5,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF20L1-associated genes across cancer lineages are RCC1, SYNJ2BP-COX16, and MCM10. Each is linked with PHF20L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHF20L1-to-partner and partner-to-PHF20L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by PHF20L1-low versus PHF20L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF20L1→partner) and Y-score (partner→PHF20L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.443	+1.711	<.001	<.001	3	4
UCEC	SYNJ2BP-COX16 →	+0.202	+2.132	<.001	<.001	3	4
UCEC	MCM10 →	+0.610	+2.284	<.001	<.001	3	4
UCEC	GNPNAT1 →	+0.510	+1.906	<.001	<.001	3	3
UCEC	BNIP3L →	+0.504	+1.600	<.001	<.001	3	3
UCEC	CCNJ →	+0.316	+1.716	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,189 associations by consensus.

RCC1 by PHF20L1 expression — UCEC

Explore this box plot interactively →