Across TCGA patient cohorts, PHF2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF2-associated genes across cancer lineages are Rad50, Stathmin, and EGFR_pY1068. Each is linked with PHF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF2-to-partner and partner-to-PHF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF2→partner) and Y-score (partner→PHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.156	-1.241	.028	.015	3	3
UCEC	Stathmin →	+0.089	+1.432	.028	.005	3	3
COAD	EGFR_pY1068 →	-0.319	-3.000	.031	.034	3	2
UCEC	FoxM1 →	+0.207	+1.857	.006	<.001	3	2
UCEC	Tuberin →	+0.263	+1.402	<.001	.011	3	2
COAD	ATM →	-0.723	-3.169	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

PHF2 survival (RNA) · tumor vs normal (RNA) · all PHF2 data types