PHF1

Across TCGA patient cohorts, PHF1 mutation is significantly associated with the RNA expression of many other genes, with 2,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF1-associated genes across cancer lineages are RN7SL248P, INSL4, and CCDC163. Each is linked with PHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF1-to-partner and partner-to-PHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PHF1-low versus PHF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF1→partner) and Y-score (partner→PHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.055	+2.985	<.001	.006	3	2
SKCM	INSL4 →	+0.420	+3.013	<.001	.004	3	2
UCEC	CCDC163 →	+0.555	+3.103	<.001	<.001	3	2
UCEC	DPH3 →	+0.398	+2.721	.004	.003	3	2
UCEC	RMND1 →	+0.664	+3.042	<.001	<.001	3	2
UCEC	REXO5 →	+0.388	+2.329	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,962 associations by consensus.

RN7SL248P by PHF1 expression — UCEC

Explore this box plot interactively →