PHEX

Across TCGA patient cohorts, PHEX RNA expression is significantly associated with the go_rna of many other GO terms, with 7,169 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible PHEX-associated GO terms across cancer lineages are Cell cycle G1/S phase transition, Bleb assembly, and Pigment granule organization. Each is linked with PHEX in more than 26 cancer types. Because this analysis shows association rather than direction, both PHEX-to-partner and partner-to-PHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle G1/S phase transition grouped by PHEX-low versus PHEX-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHEX→partner) and Y-score (partner→PHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Cell cycle G1/S phase transition →	+0.073	+0.818	<.001	<.001	3	27
ESCA	Bleb assembly →	+0.088	+0.637	<.001	<.001	3	25
STAD	Pigment granule organization →	+0.054	+0.230	<.001	<.001	3	25
STAD	Regulation of ubiquitin-dependent protein catabolic process →	+0.049	+0.234	<.001	<.001	3	25
UVM	Regulation of translational initiation by eIF2 alpha phosphorylation →	+0.086	+0.118	<.001	<.001	3	24
UVM	Regulation of translational initiation in response to stress →	+0.083	+0.118	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,169 associations by consensus.

Cell cycle G1/S phase transition by PHEX expression — SCLC

Explore this box plot interactively →