PHEX

Across TCGA pan-cancer cohorts, PHEX RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PHEX data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PHEX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PHEX expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

KIRP, SKCM, and UVM are the cancer types where PHEX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.551	0.850	<.001	97	view →
SKCM	OS	Median	All	0.392	0.283	<.001	80	view →
UVM	DFS	Median	III,IV	0.250	0.807	<.001	73	view →
ACC	OS	Tertile	All	0.421	0.823	<.001	60	view →
LGG	DFS	Median	All	0.630	0.841	<.001	54	view →
KICH	DFS	Tertile	All	0.673	1.000	.009	52	view →
THCA	OS	Quartile	II,III,IV	1.000	0.933	.006	40	view →
HNSC	OS	Quartile	II,III,IV	0.585	0.755	.004	33	view →
LIHC	OS	Median	All	0.623	0.778	.003	31	view →
KIRC	DFS	Tertile	IV	0.713	0.481	.012	14	view →
THYM	DFS	Median	All	0.933	0.805	.011	13	view →
UCEC	DFS	Quartile	All	0.430	0.674	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PHEX–KIRP (OS)

Open the KIRP breakdown →