PHEX

Across TCGA patient cohorts, PHEX protein abundance is significantly associated with the RNA expression of many other genes, with 1,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHEX-associated genes across cancer lineages are POLR2F, MAPK1, and RTCB. Each is linked with PHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both PHEX-to-partner and partner-to-PHEX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHEX versus POLR2F in GBM, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHEX→partner) and Y-score (partner→PHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POLR2F →	-0.955	-1.307	.002	.005	3	2
GBM	MAPK1 →	-0.656	-1.307	<.001	<.001	3	1
GBM	RTCB →	-0.394	-0.894	.002	.001	3	1
GBM	TXN2 →	-0.550	-1.238	.007	.003	3	1
GBM	TM9SF1 →	+0.370	+1.348	<.001	.003	3	1
GBM	PLP2 →	+1.547	+0.925	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,962 associations by consensus.

PHEX vs POLR2F — GBM

Explore this scatter interactively →