PHEX

Across TCGA patient cohorts, PHEX mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHEX-associated genes across cancer lineages are PDK1_pS241, eEF2, and FASN. Each is linked with PHEX in more than 2 cancer types. Because this analysis shows association rather than direction, both PHEX-to-partner and partner-to-PHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by PHEX-low versus PHEX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHEX→partner) and Y-score (partner→PHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PDK1_pS241 →	-0.146	-3.312	.032	.010	3	2
UCEC	eEF2 →	+0.253	+1.584	.013	.032	3	2
COAD	FASN →	+0.510	+2.815	.017	.036	3	2
UCEC	FoxM1 →	+0.158	+1.954	.033	<.001	3	2
UCEC	Ku80 →	+0.170	+1.013	.012	.029	3	2
UCEC	MEK1 →	+0.341	+1.736	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PDK1_pS241 by PHEX expression — LUSC

Explore this box plot interactively →