PHEX

Across TCGA cell cohorts, PHEX RNA expression is significantly associated with the go_rna of many other GO terms, with 2,722 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PHEX-associated GO terms across cancer lineages are Regulation of intracellular transport, Chaperone-mediated autophagy, and Positive regulation of cellular response to transforming growth factor beta stimulus. Each is linked with PHEX in more than 9 cancer types. Because this analysis shows association rather than direction, both PHEX-to-partner and partner-to-PHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular transport grouped by PHEX-low versus PHEX-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHEX→partner) and Y-score (partner→PHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of intracellular transport →	+0.061	+0.653	<.001	.001	3	10
SOFT_TISSUE	Chaperone-mediated autophagy →	+0.124	+0.395	<.001	<.001	3	7
OESOPHAGUS	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.173	+0.603	<.001	.001	3	7
OESOPHAGUS	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.173	+0.603	<.001	.001	3	7
SKIN	Regulation of protein exit from endoplasmic reticulum →	+0.099	+0.640	.004	.003	3	7
SKIN	Positive regulation of autophagy →	+0.035	+0.517	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,722 associations by consensus.

Regulation of intracellular transport by PHEX expression — SKIN

Explore this box plot interactively →