PHEX

Across TCGA cell cohorts, PHEX mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PHEX-associated genes across cancer lineages are REG3G, C18orf63, and KRTAP10-6. Each is linked with PHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both PHEX-to-partner and partner-to-PHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by PHEX-low versus PHEX-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHEX→partner) and Y-score (partner→PHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Leukemia	KRTAP10-6 →	+0.039	+4.152	<.001	.009	3	1
BLOOD_Leukemia	KRTAP10-12 →	+0.190	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PRB4 →	+0.054	+4.276	<.001	.007	3	1
OVARY	TSPY8 →	+0.052	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

REG3G by PHEX expression — BLOOD_Lymphoma

Explore this box plot interactively →