PHC3

Across TCGA patient cohorts, PHC3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,161 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHC3-associated genes across cancer lineages are CEP68, CNNM3-DT, and EZH1. Each is linked with PHC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PHC3-to-partner and partner-to-PHC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHC3 versus CEP68 in HNSC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC3→partner) and Y-score (partner→PHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CEP68 →	+0.555	+0.310	<.001	<.001	3	7
BRCA	CNNM3-DT →	+0.656	+0.422	.001	<.001	3	7
BRCA	EZH1 →	+0.712	+0.431	<.001	<.001	3	7
BRCA	RCOR3 →	+0.492	+0.308	<.001	<.001	3	7
UCEC	CXCL5 →	-1.606	-0.280	.001	<.001	3	6
HNSC	CBX7 →	+0.704	+0.407	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,161 associations by consensus.

PHC3 vs CEP68 — HNSC

Explore this scatter interactively →