PHC2-AS1

Across TCGA pan-cancer cohorts, PHC2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PHC2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PHC2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PHC2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

KIRC, UCS, and COAD are the cancer types where PHC2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	II,III,IV	0.398	0.672	<.001	82	view →
UCS	OS	Tertile	II,III,IV	0.729	0.229	.001	62	view →
COAD	DFS	Tertile	All	0.351	0.624	<.001	58	view →
BRCA	OS	Tertile	All	0.679	0.534	.001	42	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	30	view →
KICH	OS	Tertile	II,III,IV	0.768	1.000	.022	21	view →
PAAD	DFS	Median	All	0.143	0.355	.003	18	view →
THCA	OS	Quartile	II,III,IV	0.653	1.000	.019	16	view →
SKCM	OS	Median	IV	0.362	0.867	.012	12	view →
BLCA	OS	Tertile	IV	0.135	0.420	.014	11	view →
LGG	DFS	Quartile	All	0.592	0.834	.008	9	view →
STAD	DFS	Median	IV	0.154	0.566	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PHC2-AS1–KIRC (OS)

Open the KIRC breakdown →