PHC2-AS1

Across TCGA pan-cancer cohorts, PHC2-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PHC2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PHC2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHC2-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BLCA, HNSC, and THCA are the cancer types where PHC2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHC2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.627	<.001	10	view →
HNSC	All	All	+0.197	<.001	9	view →
THCA	Male	All	−0.466	<.001	7	view →
LUSC	All	All	+0.380	<.001	7	view →
UCEC	All	All	+0.355	.001	6	view →
CHOL	All	All	+0.337	.001	5	view →
LUAD	All	All	+0.394	<.001	3	view →
COAD	All	II,III,IV	+0.213	.014	3	view →
READ	Male	All	+0.293	.043	2	view →
KIRP	Female	II,III,IV	+0.276	.006	2	view →
STAD	All	II,III,IV	+0.260	.011	2	view →
PRAD	All	All	+0.181	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PHC2-AS1–BLCA

Open the BLCA breakdown →