PHBP8

Across TCGA pan-cancer cohorts, PHBP8 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PHBP8 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher PHBP8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHBP8 expression acts as an unfavorable survival marker, although some lineages such as PCPG and READ show a favorable association.

MESO, PAAD, and OV are the cancer types where PHBP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.227	0.425	<.001	107	view →
PAAD	OS	Tertile	All	0.251	0.468	.001	62	view →
OV	OS	Quartile	III,IV	0.264	0.388	.004	54	view →
UVM	OS	Quartile	II,III,IV	0.510	0.766	.003	52	view →
KIRC	DFS	Tertile	IV	0.248	0.537	.028	18	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
SKCM	OS	Median	IV	0.297	0.778	.004	12	view →
STAD	OS	Quartile	III,IV	0.242	0.472	.024	9	view →
PCPG	DFS	Tertile	All	1.000	0.715	.021	9	view →
READ	OS	Tertile	III,IV	1.000	0.441	.024	8	view →
COAD	DFS	Quartile	All	0.885	0.744	.021	3	view →
SARC	OS	Tertile	All	0.729	0.851	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PHBP8–MESO (DFS)

Open the MESO breakdown →