PHBP8

Across TCGA pan-cancer cohorts, PHBP8 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PHBP8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PHBP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHBP8 is over-expressed in tumor.

HNSC, COAD, and LUAD are the cancer types where PHBP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHBP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.042	<.001	12	view →
COAD	Female	All	+0.673	<.001	7	view →
LUAD	All	II,III,IV	+0.101	<.001	6	view →
STAD	All	II,III,IV	+0.215	.016	4	view →
CHOL	All	II,III,IV	+0.135	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PHBP8–HNSC

Open the HNSC breakdown →