PHBP6

Across TCGA patient cohorts, PHBP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,440 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible PHBP6-associated GO terms across cancer lineages are Regulation of protein kinase C signaling, Regulation of mitochondrial fission, and Positive regulation of release of cytochrome c from mitochondria. Each is linked with PHBP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHBP6-to-partner and partner-to-PHBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein kinase C signaling grouped by PHBP6-low versus PHBP6-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHBP6→partner) and Y-score (partner→PHBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of protein kinase C signaling →	+0.035	+0.021	<.001	.003	3	2
ESCA	Regulation of mitochondrial fission →	+0.040	+0.033	<.001	.001	3	2
ESCA	Positive regulation of release of cytochrome c from mitochondria →	+0.052	+0.024	<.001	<.001	3	2
ESCA	Positive regulation of protein deacetylation →	+0.043	+0.025	<.001	<.001	3	2
COAD	Lysosomal membrane organization →	+0.057	+0.008	.006	.005	3	2
ESCA	Vesicle-mediated transport in synapse →	+0.042	+0.042	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,440 associations by consensus.

Regulation of protein kinase C signaling by PHBP6 expression — ESCA

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