PHBP18

Across TCGA pan-cancer cohorts, PHBP18 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PHBP18’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PHBP18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHBP18 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

COAD, KICH, and KIRP are the cancer types where PHBP18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHBP18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.251	<.001	6	view →
KICH	Male	II,III,IV	−0.087	.024	2	view →
KIRP	All	IV	−0.065	<.001	2	view →
LUSC	All	All	+0.033	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PHBP18–COAD

Open the COAD breakdown →