PHACTR4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PHACTR4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHACTR4-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with PHACTR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHACTR4-to-partner and partner-to-PHACTR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR4→partner) and Y-score (partner→PHACTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.564-1.687<.001.04033
UCECeEF2 →+0.376+2.087.001.00532
UCECeIF4E →+0.196+3.713.006<.00132
UCECKu80 →+0.216+1.820.007.00232
UCECmTOR_pS2448 →-0.138-2.209.006.00932
UCECPDCD4 →-0.409-1.247.010.04532
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration