Across TCGA pan-cancer cohorts, PHACTR4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PHACTR4’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where PHACTR4 RNA is repressed in tumor relative to normal tissue. In most cancer types PHACTR4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, KICH, and LIHC are the cancer types where PHACTR4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHACTR4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.