Across TCGA cell cohorts, PHACTR4 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHACTR4-associated genes across cancer lineages are MMP26, C20orf85, and OR1L4. Each is linked with PHACTR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHACTR4-to-partner and partner-to-PHACTR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR4→partner) and Y-score (partner→PHACTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.019	+2.632	.005	.002	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	TBATA →	+0.013	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	SPRR1A →	+0.233	+4.930	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Exploration

PHACTR4 survival (RNA) · tumor vs normal (RNA) · all PHACTR4 data types