Across TCGA cell cohorts, PHACTR4 mutation is significantly associated with the mutation status of many other genes, with 2,992 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHACTR4-associated genes across cancer lineages are SHKBP1, AP2A1, and KCNH3. Each is linked with PHACTR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHACTR4-to-partner and partner-to-PHACTR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR4→partner) and Y-score (partner→PHACTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SHKBP1 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	AP2A1 →	+4.014	+4.969	.008	.008	1	4
SKIN	KCNH3 →	+4.772	+4.772	<.001	<.001	1	4
SOFT_TISSUE	NISCH →	+4.502	+5.066	.007	.007	1	4
UPPER_AERODIGESTIVE_TRACT	FKBP15 →	+5.392	+5.392	.004	.004	1	4
SKIN	CRYBG1 →	+5.357	+4.392	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,992 associations by consensus.

Exploration

PHACTR4 survival (RNA) · tumor vs normal (RNA) · all PHACTR4 data types