PHACTR3

Across TCGA patient cohorts, PHACTR3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHACTR3-associated genes across cancer lineages are TFRC, Cyclin-E2, and Mre11. Each is linked with PHACTR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHACTR3-to-partner and partner-to-PHACTR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PHACTR3-low versus PHACTR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR3→partner) and Y-score (partner→PHACTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.567	+2.700	.001	.005	3	3
UCEC	Cyclin-E2 →	+0.146	+1.807	.010	.004	3	3
LUSC	Mre11 →	-0.119	-2.312	.021	.035	3	2
LUSC	PDCD4 →	+0.594	+2.349	.001	.019	3	2
SKCM	FoxM1 →	+0.252	+3.169	.024	.019	1	4
UCEC	JNK2 →	+0.203	+2.097	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

TFRC by PHACTR3 expression — UCEC

Explore this box plot interactively →