PHACTR3

Across TCGA pan-cancer cohorts, PHACTR3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PHACTR3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PHACTR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHACTR3 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

THCA, LUSC, and KICH are the cancer types where PHACTR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHACTR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.887	<.001	10	view →
LUSC	Female	II,III,IV	−2.307	<.001	9	view →
KICH	Male	II,III,IV	−1.002	<.001	8	view →
HNSC	All	All	+0.439	.002	8	view →
LIHC	Male	All	−0.237	<.001	8	view →
KIRC	Male	IV	−0.790	<.001	6	view →
UCEC	All	All	−0.633	<.001	6	view →
COAD	All	All	+0.450	.003	4	view →
PAAD	All	All	+2.365	.020	2	view →
LUAD	All	IV	−1.010	.011	2	view →
PRAD	All	All	−0.102	.033	2	view →
BLCA	All	III,IV	+0.673	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PHACTR3–THCA

Open the THCA breakdown →