PHACTR3

Across TCGA cell cohorts, PHACTR3 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHACTR3-associated genes across cancer lineages are KAAG1, MOGAT2, and SIGLEC5. Each is linked with PHACTR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHACTR3-to-partner and partner-to-PHACTR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by PHACTR3-low versus PHACTR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR3→partner) and Y-score (partner→PHACTR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KAAG1 →	+0.069	+3.177	<.001	.004	3	2
BLOOD_Leukemia	MOGAT2 →	+0.038	+3.791	<.001	<.001	3	2
OESOPHAGUS	SIGLEC5 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	BANF2 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A6E →	+0.050	+4.906	<.001	.006	3	1
OESOPHAGUS	PTF1A →	+0.346	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

KAAG1 by PHACTR3 expression — BLOOD_Leukemia

Explore this box plot interactively →