PHACTR3-AS1

Across TCGA pan-cancer cohorts, PHACTR3-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated PHACTR3-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PHACTR3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PHACTR3-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

LUSC, DLBC, and UCS are the cancer types where PHACTR3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	II,III,IV	0.272	0.744	.006	72	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
LIHC	DFS	Tertile	All	0.034	0.554	<.001	36	view →
KIRC	DFS	Quartile	All	0.779	0.593	.001	35	view →
ACC	OS	Tertile	All	0.147	0.685	.018	18	view →
READ	DFS	Tertile	All	0.194	0.567	.025	18	view →
LGG	DFS	Quartile	All	0.877	0.760	.003	12	view →
THCA	DFS	Tertile	All	0.545	0.841	.011	9	view →
UCEC	DFS	Tertile	All	0.786	0.901	.047	6	view →
SKCM	OS	Tertile	II,III,IV	0.204	0.321	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PHACTR3-AS1–LUSC (OS)

Open the LUSC breakdown →