PHACTR2P1

Across TCGA pan-cancer cohorts, PHACTR2P1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PHACTR2P1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PHACTR2P1 RNA is repressed in tumor relative to normal tissue. In most cancer types PHACTR2P1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where PHACTR2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHACTR2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.273	<.001	7	view →
HNSC	All	III,IV	+0.047	.031	5	view →
BRCA	All	III,IV	−0.177	.014	4	view →
KICH	All	All	−0.131	.002	3	view →
LIHC	All	All	+0.019	.012	3	view →
READ	All	III,IV	−0.145	.001	2	view →
UCEC	All	All	−0.142	.009	2	view →
CHOL	All	All	+0.102	.011	2	view →
ESCA	Female	All	+0.510	.022	1	view →
COAD	Female	IV	+0.310	.016	1	view →
KIRP	Female	All	+0.113	.033	1	view →
KIRP	Male	All	−0.101	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

PHACTR2P1–THCA

Open the THCA breakdown →