PHACTR2

Across TCGA cell cohorts, PHACTR2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHACTR2-associated genes across cancer lineages are NAT8B, CYP4F8, and MGAT4D. Each is linked with PHACTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHACTR2-to-partner and partner-to-PHACTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAT8B grouped by PHACTR2-low versus PHACTR2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR2→partner) and Y-score (partner→PHACTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NAT8B →	+0.050	+4.228	.001	.006	3	2
SOFT_TISSUE	CYP4F8 →	+0.031	+4.882	<.001	.001	3	1
SOFT_TISSUE	MGAT4D →	+0.005	+4.977	<.001	.002	3	1
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
CNS	TMIGD1 →	+0.028	+4.169	<.001	.008	3	1
LARGE_INTESTINE	SH3GL2 →	+1.342	+3.252	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

NAT8B by PHACTR2 expression — OVARY

Explore this box plot interactively →