PHACTR2

Across TCGA pan-cancer cohorts, PHACTR2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PHACTR2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PHACTR2 RNA is repressed in tumor relative to normal tissue. In most cancer types PHACTR2 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KICH are the cancer types where PHACTR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHACTR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.526	<.001	8	view →
LUSC	Female	All	−1.454	<.001	8	view →
KICH	All	II,III,IV	−0.915	<.001	8	view →
THCA	All	All	−0.482	<.001	7	view →
UCEC	All	All	−0.943	<.001	6	view →
BRCA	All	III,IV	−0.580	<.001	6	view →
CHOL	All	II,III,IV	+1.655	.004	4	view →
KIRC	All	All	+0.338	.002	2	view →
BLCA	Female	IV	+1.226	.039	1	view →
HNSC	Female	III,IV	+0.691	.034	1	view →
READ	Female	All	−0.540	.034	1	view →
COAD	Female	All	−0.447	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PHACTR2–LUAD

Open the LUAD breakdown →