PHACTR2

Across TCGA cell cohorts, PHACTR2 mutation is significantly associated with the mutation status of many other genes, with 2,190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHACTR2-associated genes across cancer lineages are CUX1, URB2, and SCN2A. Each is linked with PHACTR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHACTR2-to-partner and partner-to-PHACTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUX1 grouped by PHACTR2-low versus PHACTR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR2→partner) and Y-score (partner→PHACTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUX1 →	+2.000	+2.662	.008	.008	1	4
OVARY	URB2 →	+4.217	+4.217	.001	.001	1	4
OESOPHAGUS	SCN2A →	+3.672	+4.307	.004	.004	1	3
LARGE_INTESTINE	PSD →	+2.263	+3.392	.001	.001	1	3
LUNG_SCLC	IKZF4 →	+5.502	+5.502	.003	.003	1	3
BLOOD_Leukemia	NCOA5 →	+6.321	+6.321	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,190 associations by consensus.

CUX1 by PHACTR2 expression — LARGE_INTESTINE

Explore this box plot interactively →