PGS1

Across TCGA pan-cancer cohorts, PGS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PGS1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PGS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where PGS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.601	0.868	.002	23	view →
UCEC	DFS	Tertile	II,III,IV	0.891	0.412	.038	10	view →
LSCC	OS	Tertile	II,III,IV	0.910	0.589	.015	4	view →
CCRCC	DFS	Quartile	All	0.890	1.000	.010	1	view →
LUAD	DFS	Quartile	All	1.000	0.602	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PGS1–PDAC (DFS)

Open the PDAC breakdown →