PGS1

Across TCGA patient cohorts, PGS1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGS1-associated genes across cancer lineages are Cyclin-B1, MSH2, and Caveolin-1. Each is linked with PGS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGS1-to-partner and partner-to-PGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PGS1-low versus PGS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGS1→partner) and Y-score (partner→PGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.577	+2.584	.006	.010	3	2
UCEC	MSH2 →	-0.219	-1.848	.011	.049	3	2
SKCM	Caveolin-1 →	-0.810	-3.321	.006	.009	3	1
SKCM	Chk2 →	+0.343	+2.459	.001	.020	3	1
UCEC	eIF4E →	+0.179	+3.335	.023	.005	3	1
UCEC	eIF4G →	+0.278	+2.459	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Cyclin-B1 by PGS1 expression — UCEC

Explore this box plot interactively →