PGRMC1

Across TCGA patient cohorts, PGRMC1 mutation is significantly associated with the RNA expression of many other genes, with 2,871 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGRMC1-associated genes across cancer lineages are OR4G6P, TRAJ20, and OR7E148P. Each is linked with PGRMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGRMC1-to-partner and partner-to-PGRMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4G6P grouped by PGRMC1-low versus PGRMC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC1→partner) and Y-score (partner→PGRMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR4G6P →	+0.044	+7.640	<.001	.009	3	1
LUSC	TRAJ20 →	+0.764	+4.286	<.001	.003	3	1
LUSC	OR7E148P →	+0.057	+4.286	.002	.003	3	1
LUSC	IGHD1-14 →	+1.404	+4.324	<.001	.002	3	1
LUSC	MTND5P26 →	+0.037	+4.754	.007	.001	3	1
LUSC	MIR4518 →	+0.384	+4.150	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,871 associations by consensus.

OR4G6P by PGRMC1 expression — BLCA

Explore this box plot interactively →