PGR

Across TCGA pan-cancer cohorts, PGR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PGR data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PGR mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PGR expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where PGR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.931	0.469	.004	12	view →
HNSC	OS	Tertile	IV	0.891	0.418	.014	10	view →
CCRCC	DFS	Median	III,IV	0.140	0.830	.038	6	view →
PDAC	OS	Quartile	II,III,IV	0.813	0.285	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PGR–LUAD (OS)

Open the LUAD breakdown →