PGR

Across TCGA patient cohorts, PGR protein abundance is significantly associated with the RNA expression of many other genes, with 8,281 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PGR-associated genes across cancer lineages are SLC25A16, PPP1R42, and CABCOCO1. Each is linked with PGR in more than 2 cancer types. Because this analysis shows association rather than direction, both PGR-to-partner and partner-to-PGR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGR versus SLC25A16 in LUAD, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGR→partner) and Y-score (partner→PGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC25A16 →	+0.693	+0.498	.001	.003	3	3
UCEC	PPP1R42 →	+0.803	+0.711	<.001	<.001	3	3
UCEC	CABCOCO1 →	+1.845	+0.802	<.001	<.001	3	3
UCEC	PHF21B →	+1.019	+0.604	<.001	<.001	3	3
UCEC	FAM189A2 →	+1.608	+0.766	<.001	<.001	3	3
BRCA	NEIL1 →	+1.113	+1.291	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,281 associations by consensus.

PGR vs SLC25A16 — LUAD

Explore this scatter interactively →