PGR

Across TCGA patient cohorts, PGR mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PGR-associated genes across cancer lineages are 4E-BP1, DJ-1, and VHL. Each is linked with PGR in more than 2 cancer types. Because this analysis shows association rather than direction, both PGR-to-partner and partner-to-PGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PGR-low versus PGR-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGR→partner) and Y-score (partner→PGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.287	+3.000	.022	.034	3	3
COAD	DJ-1 →	+0.208	+3.330	.016	.005	3	3
STAD	VHL →	+0.856	+2.584	.009	.010	3	2
UCEC	STAT3_pY705 →	-0.316	-2.115	.005	.019	3	2
COAD	p27_pT157 →	+0.183	+3.330	.007	.005	3	2
COAD	CDK1 →	+0.339	+2.178	<.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by PGR expression — STAD

Explore this box plot interactively →