PGR

Across TCGA cell cohorts, PGR RNA expression is significantly associated with the go_rna of many other GO terms, with 729 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PGR-associated GO terms across cancer lineages are Calcium ion transmembrane transport, Regulation of sulfur metabolic process, and Establishment of protein localization to membrane. Each is linked with PGR in more than 4 cancer types. Because this analysis shows association rather than direction, both PGR-to-partner and partner-to-PGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium ion transmembrane transport grouped by PGR-low versus PGR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGR→partner) and Y-score (partner→PGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Calcium ion transmembrane transport →	-0.062	-0.097	<.001	.007	2	5
OVARY	Regulation of sulfur metabolic process →	+0.074	+0.141	<.001	.005	3	3
LUNG_NSCLC_LUAD	Establishment of protein localization to membrane →	+0.026	+0.048	.007	.008	3	3
LUNG_SCLC	Positive regulation of triglyceride storage →	-0.668	-0.336	.008	.009	3	3
LUNG_SCLC	Prostate gland morphogenesis →	-0.819	-0.490	.002	.006	3	3
BREAST	Regulation of ketone metabolic process →	-0.042	-1.725	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 729 associations by consensus.

Calcium ion transmembrane transport by PGR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →