PGLYRP1

Across TCGA patient cohorts, PGLYRP1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGLYRP1-associated genes across cancer lineages are VHL, YAP_pS127, and eIF4E. Each is linked with PGLYRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP1-to-partner and partner-to-PGLYRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PGLYRP1-low versus PGLYRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP1→partner) and Y-score (partner→PGLYRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.993	-3.169	.007	.020	3	1
UCEC	YAP_pS127 →	+0.409	+3.000	.021	.036	2	1
UCEC	eIF4E →	+0.292	+3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

VHL by PGLYRP1 expression — UCEC

Explore this box plot interactively →