PGLYRP1

Across TCGA pan-cancer cohorts, PGLYRP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PGLYRP1 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PGLYRP1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PGLYRP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and THYM are the cancer types where PGLYRP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.735	0.540	<.001	94	view →
BLCA	OS	Median	IV	0.584	0.349	.003	36	view →
THYM	DFS	Tertile	All	0.930	0.432	.001	26	view →
OV	OS	Median	All	0.804	0.873	.020	26	view →
MESO	OS	Tertile	All	0.333	0.844	.002	24	view →
READ	DFS	Median	III,IV	0.847	0.634	.008	22	view →
LGG	DFS	Tertile	All	0.778	0.884	.001	17	view →
LUSC	OS	Median	III,IV	0.519	0.200	.004	13	view →
PAAD	DFS	Quartile	All	0.454	0.204	.027	12	view →
LIHC	DFS	Tertile	III,IV	0.611	0.208	<.001	11	view →
ACC	DFS	Tertile	All	0.198	0.595	.030	10	view →
UCEC	DFS	Median	II,III,IV	0.769	0.876	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PGLYRP1–HNSC (OS)

Open the HNSC breakdown →