PGK2

Across TCGA patient cohorts, PGK2 mutation is significantly associated with the RNA expression of many other genes, with 3,598 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PGK2-associated genes across cancer lineages are FAM177A1, LARP1B, and ALPL. Each is linked with PGK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGK2-to-partner and partner-to-PGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1 grouped by PGK2-low versus PGK2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGK2→partner) and Y-score (partner→PGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FAM177A1 →	+0.345	+2.257	.002	.005	3	4
UCEC	LARP1B →	+0.442	+2.638	.005	<.001	3	3
LUSC	ALPL →	-1.080	-2.807	.001	.003	3	3
LUSC	MAOB →	-0.856	-2.662	.002	<.001	3	3
UCEC	PDF →	+0.697	+2.609	<.001	.005	3	3
UCEC	MRPS18C →	+0.380	+2.108	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

FAM177A1 by PGK2 expression — LUSC

Explore this box plot interactively →