PGK2

Across TCGA pan-cancer cohorts, PGK2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated PGK2 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher PGK2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PGK2 expression acts as an unfavorable survival marker, although some lineages such as READ and ACC show a favorable association.

READ, SCLC, and THYM are the cancer types where PGK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.845	0.275	.001	55	view →
SCLC	DFS	Tertile	III,IV	0.233	0.863	.017	20	view →
THYM	OS	Tertile	IV	0.294	1.000	.025	18	view →
STAD	OS	Tertile	All	0.323	0.657	.008	15	view →
KIRC	DFS	Quartile	III,IV	0.402	0.676	.009	12	view →
SARC	OS	Tertile	All	0.686	0.835	.004	12	view →
ACC	DFS	Tertile	All	0.856	0.470	.026	9	view →
SKCM	OS	Tertile	III,IV	0.653	0.322	.014	8	view →
ESCA	DFS	Quartile	II,III,IV	0.356	0.560	.019	8	view →
UCS	OS	Tertile	All	0.194	0.429	.037	6	view →
BLCA	DFS	Quartile	III,IV	0.494	0.607	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PGK2–READ (DFS)

Open the READ breakdown →