PGK2

Across TCGA patient cohorts, PGK2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGK2-associated genes across cancer lineages are ASNS, JNK2, and eIF4G. Each is linked with PGK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGK2-to-partner and partner-to-PGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PGK2-low versus PGK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGK2→partner) and Y-score (partner→PGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.472	+2.000	.001	.030	3	3
UCEC	JNK2 →	+0.242	+2.196	.003	.032	3	2
UCEC	eIF4G →	+0.320	+3.459	.012	.005	3	2
UCEC	FoxM1 →	+0.274	+2.321	.010	.006	3	2
UCEC	ACC1 →	+0.327	+1.807	.029	.027	3	2
UCEC	STAT3_pY705 →	-0.510	-2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ASNS by PGK2 expression — UCEC

Explore this box plot interactively →