PGK2

Across TCGA cell cohorts, PGK2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PGK2-associated genes across cancer lineages are OR13C4, PRLHR, and CACNG2. Each is linked with PGK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGK2-to-partner and partner-to-PGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C4 grouped by PGK2-low versus PGK2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGK2→partner) and Y-score (partner→PGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR13C4 →	+0.093	+4.029	<.001	<.001	3	1
BLOOD_Leukemia	PRLHR →	+0.023	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CACNG2 →	+0.016	+5.539	<.001	.003	3	1
CNS	LCE3A →	+0.383	+5.754	<.001	.002	3	1
CNS	CD300LD →	+0.042	+5.754	<.001	.002	3	1
OVARY	OR8D1 →	+0.014	+4.228	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR13C4 by PGK2 expression — LUNG_SCLC

Explore this box plot interactively →